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M., Mahajan, A., Agarwala, V., Gaulton, K. Fuchsberger, C., Flannick, J., Teslovich, T.Thirst neurons anticipate the homeostatic consequences of eating and drinking. miR-30 Family Controls Proliferation and Differentiation of Intestinal Epithelial Cell Models by Directing a Broad Gene Expression Program That Includes SOX9 and the Ubiquitin Ligase Pathway. E., Sincavage, J., Feinstein, S., Mah, A.

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Detection and manipulation of live antigen-expressing cells using conditionally stable nanobodies. C., Drokhlyansky, E., Etemad, B., Rudolph, S., Guo, B., Wang, S., … Cepko, C. Branched-chain amino acid restriction in Zucker-fatty rats improves muscle insulin sensitivity by enhancing efficiency of fatty acid oxidation and acyl-glycine export. Heterogeneous Contribution of Insulin Sensitivity and Secretion Defects to Gestational Diabetes Mellitus. E., Allard, C., Battista, M.-C., Doyon, M., Bouchard, L., Ecker, J. The genetic regulatory signature of type 2 diabetes in human skeletal muscle. The Journal of Allergy and Clinical Immunology, 138(3), 839-851.e8. T-helper signals restore B-cell receptor signaling in autoreactive anergic B cells by upregulating CD45 phosphatase activity. Microneedles Integrated with Pancreatic Cells and Synthetic Glucose-Signal Amplifiers for Smart Insulin Delivery. Restoration of Nrf2 Signaling Normalizes the Regenerative Niche. A., Ellison, T., Anil, U., … Ceradini, D. Investigative Ophthalmology & Visual Science, 57(3), 1327–1337.

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The Translational Repressor 4E-BP1 Contributes to Diabetes-Induced Visual Dysfunction. Pathogenic CD4 T cells in type 1 diabetes recognize epitopes formed by peptide fusion. L., Bradley, B., Barbour, G., Reisdorph, R., … Haskins, K. Glucosamine induces REDD1 to suppress insulin action in retinal Müller cells. Proceedings of the National Academy of Sciences of the United States of America, 112(49), 15226–15231. Acceleration of diabetic wound healing using a novel protease-anti-protease combination therapy. R., Gooyit, M., Mobashery, S., & Chang, M. 2015 (Cover Feature Young Innovators Special Issue). Engineering Synthetic Insulin-Secreting Cells Using Hyaluronic Acid Microgels Integrated with Glucose-Responsive Nanoparticles. Stretch-Triggered Drug Delivery from Wearable Elastomer Films Containing Therapeutic Depots. Proceedings of the National Academy of Sciences of the United States of America, 112(27), 8260–8265. Microneedle-array patches loaded with hypoxia-sensitive vesicles provide fast glucose-responsive insulin delivery. Yu, J., Zhang, Y., Ye, Y., DiSanto, R., Sun, W., Ranson, D., … Gu, Z.

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Targeting the disordered C terminus of PTP1B with an allosteric inhibitor. The Journal of Clinical Investigation, 125(8), 3163–3177. PTP1B inhibition suggests a therapeutic strategy for Rett syndrome.

  • Krishnan, N., Krishnan, K., Connors, C.
  • Motif signatures in stretch enhancers are enriched for disease-associated genetic variants. Regulated in development and DNA damage 1 is necessary for hyperglycemia-induced vascular endothelial growth factor expression in the retina of diabetic rodents. REDD1 enhances protein phosphatase 2A-mediated dephosphorylation of Akt to repress mTORC1 signaling.












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